Research interests: Her current scientific research is aimed to development of nanoparticles for biochemical and biomedical applications. It concerns the conception of new systems for drug delivery and targeting (colloidal and polymeric nanoparticles, nanoemulsions, prodrugs etc.). Her research interests focus on synthesis, characterization of colloidal nanoparticles and bio-functionalization using different approaches and different active bio-ligands for biomedical application mainly in the oncology field.
In order to support her research in new drug delivery nanosystems, in the past few years she has looked into new administration methods of nanoparticles rather than traditional intravenous ones, in particular oral and topic administrations.
https://www.scopus.com/authid/detail.uri?authorId=24922603100 (Scopus)
http://www.btbs.unimib.it/?personale-type=miriam-colombo&lang=en (Unimib)
Pubblicazioni Miriam Colombo
2020 - Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment: Salvioni, L., Zuppone, S., Andreata, F., Monieri, M., Mazzucchelli, S., Di Carlo, C., et al. (2020). Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment. ADVANCED THERAPEUTICS, 3(8).2020 - Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia: Das, P., Salvioni, L., Malatesta, M., Vurro, F., Mannucci, S., Gerosa, M., et al. (2020). Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 579, 186-194.2020 - Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles: Fatehbasharzad, P., Stefania, R., Carrera, C., Hawala, I., Castelli, D., Baroni, S., et al. (2020). Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles. NANOMATERIALS, 10(6), 1-15.2020 - MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging: Mauri, M., Collico, V., Morelli, L., Das, P., Garcia, I., Penaranda Avila, J., et al. (2020). MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging. ACS APPLIED NANO MATERIALS, 3(4), 3787-3797.2020 - Targeted delivery of nanoparticles: Rotem, R., Prosperi, D., & Colombo, M. (2020). Targeted delivery of nanoparticles. In Frontiers of Nanoscience (pp. 253-264). Elsevier Ltd.2020 - Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer: Bellini, M., Riva, B., Tinelli, V., Rizzuto, M., Salvioni, L., Colombo, M., et al. (2020). Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer. SMALL, 16(39).2020 - Modeling the interaction of amphiphilic polymer nanoparticles with biomembranes to Guide rational design of drug delivery systems: Rotem, R., Micale, A., Rizzuto, M., Migliavacca, M., Giustra, M., Salvioni, L., et al. (2020). Modeling the interaction of amphiphilic polymer nanoparticles with biomembranes to Guide rational design of drug delivery systems. COLLOIDS AND SURFACES. B, BIOINTERFACES, 196.2020 - Functionalization of colloidal nanoparticles with a discrete number of ligands based on a “HALO-bioclick” reaction: Garbujo, S., Galbiati, E., Salvioni, L., Mazzucchelli, M., Frascotti, G., Sun, X., et al. (2020). Functionalization of colloidal nanoparticles with a discrete number of ligands based on a “HALO-bioclick” reaction. CHEMICAL COMMUNICATIONS, 56(77), 11398-11401.2020 - Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome: Pandolfi, L., Fusco, R., Frangipane, V., D'Amico, R., Giustra, M., Bozzini, S., et al. (2020). Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome. SCIENTIFIC REPORTS, 10(1).
Pubblicazioni unificate
2020 - Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome: Pandolfi, L., Fusco, R., Frangipane, V., D'Amico, R., Giustra, M., Bozzini, S., et al. (2020). Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome. SCIENTIFIC REPORTS, 10(1).2020 - Curcumin Formulations and Trials: What’s New in Neurological Diseases: Gagliardi, S., Morasso, C., Stivaktakis, P., Pandini, C., Tinelli, V., Tsatsakis, A., et al. (2020). Curcumin Formulations and Trials: What’s New in Neurological Diseases. MOLECULES, 25(22).2020 - Anti-madcam-1-conjugated nanocarriers delivering quantum dots enable specific imaging of inflammatory bowel disease: Truffi, M., Sevieri, M., Morelli, L., Monieri, M., Mazzucchelli, S., Sorrentino, L., et al. (2020). Anti-madcam-1-conjugated nanocarriers delivering quantum dots enable specific imaging of inflammatory bowel disease. INTERNATIONAL JOURNAL OF NANOMEDICINE, 15, 8537-8552.2018 - Olaparib nanoformulation in H-Ferritin for the triple negative breast cancer treatment: Mazzucchelli, S., Truffi, M., Sorrentino, L., Bellini, M., Ottria, R., Ravelli, A., et al. (2018). Olaparib nanoformulation in H-Ferritin for the triple negative breast cancer treatment. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2015 - Detection of nanostructures in solutions of Zincum metallicum and the vehicle lactose: Marzotto, M., Bonafini, C., Olioso, D., Holandino, C., Bonamin, L., Prosperi, D., et al. (2015). Detection of nanostructures in solutions of Zincum metallicum and the vehicle lactose. Intervento presentato a: Proceedings of the XXIX GIRI, Verona.2017 - Metronomic nanocaged doxorubicin prevents chemoresistance and cardiotoxicity in breast cancer: Mazzucchelli, S., Truffi, M., Bellini, M., Rizzuto, M., Prosperi, D., & Corsi, F. (2017). Metronomic nanocaged doxorubicin prevents chemoresistance and cardiotoxicity in breast cancer. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2019 - Half-Chain trastuzumab nanoconjugates enhance antitumor activity in HER2+ breast cancer: Truffi, M., Colombo, M., Sorrentino, L., Mazzucchelli, S., Pandolfi, L., Bonizzi, A., et al. (2019). Half-Chain trastuzumab nanoconjugates enhance antitumor activity in HER2+ breast cancer. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2018 - MAdCAM-1 nanotargeting uncovers bowel inflammation foci in experimental model of colitis: Truffi, M., Colombo, M., Sorrentino, L., Mazzucchelli, S., Monieri, M., Longhi, E., et al. (2018). MAdCAM-1 nanotargeting uncovers bowel inflammation foci in experimental model of colitis. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2017 - Meet our editor-in-chief: Prosperi, D. (2017). Meet our editor-in-chief. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 18(6), 441-441.2019 - Cetuximab-conjugates nanoparticles for the treatment of triple negative breast cancer: Bonizzi, A., Colombo, M., Rizzuto, M., Pacini, C., Pandolfi, L., Truffi, M., et al. (2019). Cetuximab-conjugates nanoparticles for the treatment of triple negative breast cancer. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2020 - Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer: Bellini, M., Riva, B., Tinelli, V., Rizzuto, M., Salvioni, L., Colombo, M., et al. (2020). Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer. SMALL, 16(39).2020 - Modeling the interaction of amphiphilic polymer nanoparticles with biomembranes to Guide rational design of drug delivery systems: Rotem, R., Micale, A., Rizzuto, M., Migliavacca, M., Giustra, M., Salvioni, L., et al. (2020). Modeling the interaction of amphiphilic polymer nanoparticles with biomembranes to Guide rational design of drug delivery systems. COLLOIDS AND SURFACES. B, BIOINTERFACES, 196.2020 - Functionalization of colloidal nanoparticles with a discrete number of ligands based on a “HALO-bioclick” reaction: Garbujo, S., Galbiati, E., Salvioni, L., Mazzucchelli, M., Frascotti, G., Sun, X., et al. (2020). Functionalization of colloidal nanoparticles with a discrete number of ligands based on a “HALO-bioclick” reaction. CHEMICAL COMMUNICATIONS, 56(77), 11398-11401.2020 - Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment: Salvioni, L., Zuppone, S., Andreata, F., Monieri, M., Mazzucchelli, S., Di Carlo, C., et al. (2020). Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment. ADVANCED THERAPEUTICS, 3(8).2020 - Targeted delivery of nanoparticles: Rotem, R., Prosperi, D., & Colombo, M. (2020). Targeted delivery of nanoparticles. In Frontiers of Nanoscience (pp. 253-264). Elsevier Ltd.2020 - Preface frontiers in cancer immunotherapy: Understanding the role of gut microbiota: Prosperi, D. (2020). Preface frontiers in cancer immunotherapy: Understanding the role of gut microbiota. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 21(1), 2-2.2020 - MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging: Mauri, M., Collico, V., Morelli, L., Das, P., Garcia, I., Penaranda Avila, J., et al. (2020). MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging. ACS APPLIED NANO MATERIALS, 3(4), 3787-3797.2020 - Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles: Fatehbasharzad, P., Stefania, R., Carrera, C., Hawala, I., Castelli, D., Baroni, S., et al. (2020). Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles. NANOMATERIALS, 10(6), 1-15.2020 - Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface: Tira, R., De Cecco, E., Rigamonti, V., Santambrogio, C., Barracchia, C., Munari, F., et al. (2020). Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 154, 206-216.2020 - Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia: Das, P., Salvioni, L., Malatesta, M., Vurro, F., Mannucci, S., Gerosa, M., et al. (2020). Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 579, 186-194.2020 - Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2 + murine breast cancer model: Andreata, F., Bonizzi, A., Sevieri, M., Truffi, M., Monieri, M., Sitia, L., et al. (2020). Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2 + murine breast cancer model. SCIENTIFIC REPORTS, 10(1).2019 - Does conjugation strategy matter? Cetuximab-conjugated gold nanocages for targeting triple-negative breast cancer cells: Avvakumova, S., Pandolfi, L., Soprano, E., Moretto, L., Bellini, M., Galbiati, E., et al. (2019). Does conjugation strategy matter? Cetuximab-conjugated gold nanocages for targeting triple-negative breast cancer cells. NANOSCALE ADVANCES, 1(9), 3626-3638.2019 - Thirty years of cancer nanomedicine: Success, frustration, and hope: Salvioni, L., Rizzuto, M., Bertolini, J., Pandolfi, L., Colombo, M., & Prosperi, D. (2019). Thirty years of cancer nanomedicine: Success, frustration, and hope. CANCERS, 11(12).2019 - Monitoring the fate of orally administered plga nanoformulation for local delivery of therapeutic drugs: Morelli, L., Gimondi, S., Sevieri, M., Salvioni, L., Guizzetti, M., Colzani, B., et al. (2019). Monitoring the fate of orally administered plga nanoformulation for local delivery of therapeutic drugs. PHARMACEUTICS, 11(12).2019 - Are nanotechnological approaches the future of treating inflammatory diseases?: Rizzuto, M., Salvioni, L., Rotem, R., Colombo, M., Zanoni, I., Granucci, F., et al. (2019). Are nanotechnological approaches the future of treating inflammatory diseases?. NANOMEDICINE, 14(17), 2379-2390.2019 - Imatinib-loaded gold nanoparticles inhibit proliferation of fibroblasts and macrophages from systemic sclerosis patients and ameliorate experimental bleomycin-induced lung fibrosis: Codullo, V., Cova, E., Pandolfi, L., Breda, S., Morosini, M., Frangipane, V., et al. (2019). Imatinib-loaded gold nanoparticles inhibit proliferation of fibroblasts and macrophages from systemic sclerosis patients and ameliorate experimental bleomycin-induced lung fibrosis. JOURNAL OF CONTROLLED RELEASE, 310, 198-208.2019 - Multifunctional Magnetic Gold Nanomaterials for Cancer: Das, P., Fatehbasharzad, P., Colombo, M., Fiandra, L., & Prosperi, D. (2019). Multifunctional Magnetic Gold Nanomaterials for Cancer. TRENDS IN BIOTECHNOLOGY, 37(9), 995-1010.2019 - Suicide gene therapy: A new frontier for cancer fighting: Prosperi, D., & Colombo, M. (2019). Suicide gene therapy: A new frontier for cancer fighting. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 20(1), 2-4.2019 - Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study: Cova, E., Pandolfi, L., Colombo, M., Frangipane, V., Inghilleri, S., Morosini, M., et al. (2019). Pemetrexed-loaded nanoparticles targeted to malignant pleural mesothelioma cells: an in vitro study. INTERNATIONAL JOURNAL OF NANOMEDICINE, 14, 773-785.2018 - Bioengineered Approaches for Site Orientation of Peptide-Based Ligands of Nanomaterials: Avvakumova, S., Colombo, M., Galbiati, E., Mazzucchelli, S., Rotem, R., & Prosperi, D. (2018). Bioengineered Approaches for Site Orientation of Peptide-Based Ligands of Nanomaterials. In Biomedical Applications of Functionalized Nanomaterials (pp. 139-169). Elsevier.
Miriam Colombo