Miriam Colombo

Assistant Professor in Clinical Biochemistry

miriam.colombo@unimib.it

Research interests: Her current scientific research is aimed to development of nanoparticles for biochemical and biomedical applications. It concerns the conception of new systems for drug delivery and targeting (colloidal and polymeric nanoparticles, nanoemulsions, prodrugs etc.). Her research interests focus on synthesis, characterization of colloidal nanoparticles and bio-functionalization using different approaches and different active bio-ligands for biomedical application mainly in the oncology field.

In order to support her research in new drug delivery nanosystems, in the past few years she has looked into new administration methods of nanoparticles rather than traditional intravenous ones, in particular oral and topic administrations.

https://www.scopus.com/authid/detail.uri?authorId=24922603100 (Scopus)

http://www.btbs.unimib.it/?personale-type=miriam-colombo&lang=en (Unimib)

 

Pubblicazioni Miriam Colombo

2021 - H-Ferritin nanoparticle-mediated delivery of antibodies across a BBB in vitro model for treatment of brain malignancies: Rizzuto, M., Dal Magro, R., Barbieri, L., Pandolfi, L., Sguazzini-Viscontini, A., Truffi, M., et al. (2021). H-Ferritin nanoparticle-mediated delivery of antibodies across a BBB in vitro model for treatment of brain malignancies. BIOMATERIALS SCIENCE, 9(6), 2032-2042 [10.1039/d0bm01726d].2021 - 99mTc-radiolabeled silica nanocarriers for targeted detection and treatment of HER2-positive breast cancer: Rainone, P., De Palma, A., Sudati, F., Roffia, V., Rigamonti, V., Salvioni, L., et al. (2021). 99mTc-radiolabeled silica nanocarriers for targeted detection and treatment of HER2-positive breast cancer. INTERNATIONAL JOURNAL OF NANOMEDICINE, 16, 1943-1960 [10.2147/IJN.S276033].2021 - The role of polymeric coatings for a safe-by-design development of biomedical gold nanoparticles assessed in zebrafish embryo: Floris, P., Garbujo, S., Rolla, G., Giustra, M., Salvioni, L., Catelani, T., et al. (2021). The role of polymeric coatings for a safe-by-design development of biomedical gold nanoparticles assessed in zebrafish embryo. NANOMATERIALS, 11(4).2021 - The emerging role of nanotechnology in skincare: Salvioni, L., Morelli, L., Ochoa, E., Labra, M., Fiandra, L., Palugan, L., et al. (2021). The emerging role of nanotechnology in skincare. ADVANCES IN COLLOID AND INTERFACE SCIENCE, 293(July 2021) [10.1016/j.cis.2021.102437].2020 - Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment: Salvioni, L., Zuppone, S., Andreata, F., Monieri, M., Mazzucchelli, S., Di Carlo, C., et al. (2020). Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment. ADVANCED THERAPEUTICS, 3(8) [10.1002/adtp.202000007].2020 - Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia: Das, P., Salvioni, L., Malatesta, M., Vurro, F., Mannucci, S., Gerosa, M., et al. (2020). Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 579, 186-194 [10.1016/j.jcis.2020.05.119].2020 - Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles: Fatehbasharzad, P., Stefania, R., Carrera, C., Hawala, I., Castelli, D., Baroni, S., et al. (2020). Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles. NANOMATERIALS, 10(6), 1-15.2020 - MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging: Mauri, M., Collico, V., Morelli, L., Das, P., Garcia, I., Penaranda Avila, J., et al. (2020). MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging. ACS APPLIED NANO MATERIALS, 3(4), 3787-3797 [10.1021/acsanm.0c00474].2020 - Targeted delivery of nanoparticles: Rotem, R., Prosperi, D., & Colombo, M. (2020). Targeted delivery of nanoparticles. In Frontiers of Nanoscience (pp. 253-264). Elsevier Ltd [10.1016/B978-0-08-102828-5.00010-3].

Pubblicazioni unificate

2021 - The emerging role of nanotechnology in skincare: Salvioni, L., Morelli, L., Ochoa, E., Labra, M., Fiandra, L., Palugan, L., et al. (2021). The emerging role of nanotechnology in skincare. ADVANCES IN COLLOID AND INTERFACE SCIENCE, 293(July 2021) [10.1016/j.cis.2021.102437].2021 - The role of polymeric coatings for a safe-by-design development of biomedical gold nanoparticles assessed in zebrafish embryo: Floris, P., Garbujo, S., Rolla, G., Giustra, M., Salvioni, L., Catelani, T., et al. (2021). The role of polymeric coatings for a safe-by-design development of biomedical gold nanoparticles assessed in zebrafish embryo. NANOMATERIALS, 11(4).2021 - Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+mobilization and the inflammatory activity of dendritic cells: Marongiu, L., Mingozzi, F., Cigni, C., Marzi, R., Di Gioia, M., Garre, M., et al. (2021). Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+mobilization and the inflammatory activity of dendritic cells. SCIENCE SIGNALING, 14(676).2021 - 99mTc-radiolabeled silica nanocarriers for targeted detection and treatment of HER2-positive breast cancer: Rainone, P., De Palma, A., Sudati, F., Roffia, V., Rigamonti, V., Salvioni, L., et al. (2021). 99mTc-radiolabeled silica nanocarriers for targeted detection and treatment of HER2-positive breast cancer. INTERNATIONAL JOURNAL OF NANOMEDICINE, 16, 1943-1960 [10.2147/IJN.S276033].2021 - Evaluation of tfr-1 expression in feline mammary cancer and in vitro antitumor efficacy study of doxorubicin-loaded h-ferritin nanocages: Rensi, N., Sammarco, A., Moccia, V., Calore, A., Torrigiani, F., Prosperi, D., et al. (2021). Evaluation of tfr-1 expression in feline mammary cancer and in vitro antitumor efficacy study of doxorubicin-loaded h-ferritin nanocages. CANCERS, 13(6), 1-15.2021 - H-Ferritin nanoparticle-mediated delivery of antibodies across a BBB in vitro model for treatment of brain malignancies: Rizzuto, M., Dal Magro, R., Barbieri, L., Pandolfi, L., Sguazzini-Viscontini, A., Truffi, M., et al. (2021). H-Ferritin nanoparticle-mediated delivery of antibodies across a BBB in vitro model for treatment of brain malignancies. BIOMATERIALS SCIENCE, 9(6), 2032-2042 [10.1039/d0bm01726d].2021 - Selective Targeting of Cancer-Associated Fibroblasts by Engineered H-Ferritin Nanocages Loaded with Navitoclax: Sitia, L., Bonizzi, A., Mazzucchelli, S., Negri, S., Sottani, C., Grignani, E., et al. (2021). Selective Targeting of Cancer-Associated Fibroblasts by Engineered H-Ferritin Nanocages Loaded with Navitoclax. CELLS, 10(2) [10.3390/cells10020328].2020 - Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome: Pandolfi, L., Fusco, R., Frangipane, V., D'Amico, R., Giustra, M., Bozzini, S., et al. (2020). Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome. SCIENTIFIC REPORTS, 10(1).2020 - Curcumin Formulations and Trials: What’s New in Neurological Diseases: Gagliardi, S., Morasso, C., Stivaktakis, P., Pandini, C., Tinelli, V., Tsatsakis, A., et al. (2020). Curcumin Formulations and Trials: What’s New in Neurological Diseases. MOLECULES, 25(22) [10.3390/molecules25225389].2020 - Anti-madcam-1-conjugated nanocarriers delivering quantum dots enable specific imaging of inflammatory bowel disease: Truffi, M., Sevieri, M., Morelli, L., Monieri, M., Mazzucchelli, S., Sorrentino, L., et al. (2020). Anti-madcam-1-conjugated nanocarriers delivering quantum dots enable specific imaging of inflammatory bowel disease. INTERNATIONAL JOURNAL OF NANOMEDICINE, 15, 8537-8552.2018 - Olaparib nanoformulation in H-Ferritin for the triple negative breast cancer treatment: Mazzucchelli, S., Truffi, M., Sorrentino, L., Bellini, M., Ottria, R., Ravelli, A., et al. (2018). Olaparib nanoformulation in H-Ferritin for the triple negative breast cancer treatment. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2015 - Detection of nanostructures in solutions of Zincum metallicum and the vehicle lactose: Marzotto, M., Bonafini, C., Olioso, D., Holandino, C., Bonamin, L., Prosperi, D., et al. (2015). Detection of nanostructures in solutions of Zincum metallicum and the vehicle lactose. Intervento presentato a: Proceedings of the XXIX GIRI, Verona.2017 - Metronomic nanocaged doxorubicin prevents chemoresistance and cardiotoxicity in breast cancer: Mazzucchelli, S., Truffi, M., Bellini, M., Rizzuto, M., Prosperi, D., & Corsi, F. (2017). Metronomic nanocaged doxorubicin prevents chemoresistance and cardiotoxicity in breast cancer. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2019 - Half-Chain trastuzumab nanoconjugates enhance antitumor activity in HER2+ breast cancer: Truffi, M., Colombo, M., Sorrentino, L., Mazzucchelli, S., Pandolfi, L., Bonizzi, A., et al. (2019). Half-Chain trastuzumab nanoconjugates enhance antitumor activity in HER2+ breast cancer. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing [10.11159/nddte19.102].2018 - MAdCAM-1 nanotargeting uncovers bowel inflammation foci in experimental model of colitis: Truffi, M., Colombo, M., Sorrentino, L., Mazzucchelli, S., Monieri, M., Longhi, E., et al. (2018). MAdCAM-1 nanotargeting uncovers bowel inflammation foci in experimental model of colitis. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2017 - Meet our editor-in-chief: Prosperi, D. (2017). Meet our editor-in-chief. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 18(6), 441-441.2019 - Cetuximab-conjugates nanoparticles for the treatment of triple negative breast cancer: Bonizzi, A., Colombo, M., Rizzuto, M., Pacini, C., Pandolfi, L., Truffi, M., et al. (2019). Cetuximab-conjugates nanoparticles for the treatment of triple negative breast cancer. In World Congress on Recent Advances in Nanotechnology. Avestia Publishing.2020 - Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer: Bellini, M., Riva, B., Tinelli, V., Rizzuto, M., Salvioni, L., Colombo, M., et al. (2020). Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer. SMALL, 16(39).2020 - Modeling the interaction of amphiphilic polymer nanoparticles with biomembranes to Guide rational design of drug delivery systems: Rotem, R., Micale, A., Rizzuto, M., Migliavacca, M., Giustra, M., Salvioni, L., et al. (2020). Modeling the interaction of amphiphilic polymer nanoparticles with biomembranes to Guide rational design of drug delivery systems. COLLOIDS AND SURFACES. B, BIOINTERFACES, 196.2020 - Functionalization of colloidal nanoparticles with a discrete number of ligands based on a “HALO-bioclick” reaction: Garbujo, S., Galbiati, E., Salvioni, L., Mazzucchelli, M., Frascotti, G., Sun, X., et al. (2020). Functionalization of colloidal nanoparticles with a discrete number of ligands based on a “HALO-bioclick” reaction. CHEMICAL COMMUNICATIONS, 56(77), 11398-11401.2020 - Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment: Salvioni, L., Zuppone, S., Andreata, F., Monieri, M., Mazzucchelli, S., Di Carlo, C., et al. (2020). Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment. ADVANCED THERAPEUTICS, 3(8) [10.1002/adtp.202000007].2020 - Targeted delivery of nanoparticles: Rotem, R., Prosperi, D., & Colombo, M. (2020). Targeted delivery of nanoparticles. In Frontiers of Nanoscience (pp. 253-264). Elsevier Ltd [10.1016/B978-0-08-102828-5.00010-3].2020 - Preface frontiers in cancer immunotherapy: Understanding the role of gut microbiota: Prosperi, D. (2020). Preface frontiers in cancer immunotherapy: Understanding the role of gut microbiota. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 21(1), 2-2 [10.2174/138920102101191209163306].2020 - MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging: Mauri, M., Collico, V., Morelli, L., Das, P., Garcia, I., Penaranda Avila, J., et al. (2020). MnO Nanoparticles Embedded in Functional Polymers as T1 Contrast Agents for Magnetic Resonance Imaging. ACS APPLIED NANO MATERIALS, 3(4), 3787-3797 [10.1021/acsanm.0c00474].2020 - Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles: Fatehbasharzad, P., Stefania, R., Carrera, C., Hawala, I., Castelli, D., Baroni, S., et al. (2020). Relaxometric studies of Gd-Chelate conjugated on the surface of differently shaped gold nanoparticles. NANOMATERIALS, 10(6), 1-15.2020 - Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface: Tira, R., De Cecco, E., Rigamonti, V., Santambrogio, C., Barracchia, C., Munari, F., et al. (2020). Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 154, 206-216 [10.1016/j.ijbiomac.2020.03.118].2020 - Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia: Das, P., Salvioni, L., Malatesta, M., Vurro, F., Mannucci, S., Gerosa, M., et al. (2020). Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 579, 186-194 [10.1016/j.jcis.2020.05.119].2020 - Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2 + murine breast cancer model: Andreata, F., Bonizzi, A., Sevieri, M., Truffi, M., Monieri, M., Sitia, L., et al. (2020). Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2 + murine breast cancer model. SCIENTIFIC REPORTS, 10(1) [10.1038/s41598-020-68205-w].2019 - Does conjugation strategy matter? Cetuximab-conjugated gold nanocages for targeting triple-negative breast cancer cells: Avvakumova, S., Pandolfi, L., Soprano, E., Moretto, L., Bellini, M., Galbiati, E., et al. (2019). Does conjugation strategy matter? Cetuximab-conjugated gold nanocages for targeting triple-negative breast cancer cells. NANOSCALE ADVANCES, 1(9), 3626-3638 [10.1039/c9na00241c].2019 - Thirty years of cancer nanomedicine: Success, frustration, and hope: Salvioni, L., Rizzuto, M., Bertolini, J., Pandolfi, L., Colombo, M., & Prosperi, D. (2019). Thirty years of cancer nanomedicine: Success, frustration, and hope. CANCERS, 11(12) [10.3390/cancers11121855].
Miriam Colombo